She started her career off in 2010 in the indie short film, Everyday, where she played the lead role. The next year, 2011, she starred in another short film, Carpool, opposite Morgan Pavey and Andy Dulman. She gained widespread recognition in 2012 as JB's Girl in Project X. Project X was a box office success, earning $100.9m in total box office sales, on a budget of only $12m. The film received three MTV Movie Award nominations, Best Comedic Performance, Best On-Screen Dirtbag, and Best Music. She continued her success in the same year with the indie film, Model Minority, in which Nichole plays the lead role, her first lead role. The film has garnered positive reviews from critics and audiences. The film currently holds a 6.6 from audience viewers. The film won many award from the Sacramento Film Festival, London Independent Film Festival, Los Angeles Asian Pacific Film Festival, Las Vegas Film Festival, etc. Bloom also garnered a Special Jury Prize at the 28th Los Angeles Asian Pacific Film Festival for Best New Actress. Nichole has also played as a voice actor on a best selling game called Until Dawn and played the character Emily.
Nichole was born and raised in San Francisco. She has done commercial work and modeled for American Apparel. Although she cannot pinpoint the exact moment she realized she wanted to start acting, Nichole recalls that she loved recreating characters and doing funny voices from a very young age. As a kid, she begged her parents to help her get an agent, and then at the age of 14, she moved to Los Angeles to pursue acting as a career. Nichole went on to attend USC as a Theater major and graduated early, after only three years. She says it was a challenge for her to get cast in the university's own plays because she dedicated so much of her spare time to professional auditions outside of school.