He lived in a large house with his wife, away from the south side.
He is first mentioned indirectly in Nana Gallagher Had an Affair, where Fiona mentions to her siblings their father has three brothers.
In Daddyz Girl, Ian and Lip visit Clayton and his wife Lucy claiming they were working on family tree projects at school. Clayton shows pictures of him and Frank as alter boys, and says that they had a falling out, and that it was his fault but he never did anything about it. Lucy seems uncomfortable and takes Clayton out of the room to help with pop. Lip and Ian hear her saying that she doesn't want them in the house and that the latter looked like their son Jacob. Clayton tells his wife that he never slept with Ian's mother, obviously knowing the truth as his wife isn't convinced. Lip says Ian looks just like him, and that he might as well take the opportunity and share the wealth with his obvious father. Ian gets upset and they leave the house. Outside, Ian tells Lip that Fiona is his sister, just like Lip is his brother, and he is happy living with them despite all their troubles with Frank who he still regards as his father. Ian also tells him not to shift his issues on him, before he goes to the car with Clayton watching from his front door, having overheard the talk but does not protest Ian's choice. He bids his nephews goodbye as they leave.
After Peggy's death in Parenthood, Clayton was sent money by her along with Wyatt and Jerry.
During Just Like the Pilgrims Intended, Frank decides to visit him along with Monica to get money after their mother sent him some following her death. Clayton is not pleased to see his brother and when he tries to guilt him by mentioning him taking care of their ill mother before her death. Clayton justifies it by telling him, he did not know she was released. Frank asks for some of the money to make amends. However, Clayton had already used the money to pay his mortgage and orders him out. Clayton also resists Monica's advances and watches as they leave.
- A Jailbird, Invalid, Martyr, Cutter, Retard, And Parasitic Twin (mentioned only)
- He doesn't seem to mind his brother Frank, despite presumably sleeping with the latter's wife.
- He even wished to make amends with him about a previous transgression.
- Frank appears to not like Clayton that much and seems to know that he is Ian's true father, which adds more to his dislike and for being one of the favorite sons of their parents.
- He appears to be doing well for himself, in spite of being a Gallagher.
- He was the only uncle that Lip liked since he didn't send them off like Jerry.
- It is unknown if he was on good terms with his mother, as he was unaware Peggy was released.
- However, Peggy sent him money before her death and he didn't speak ill of her when talking to Frank. He also didn't hesitate to use the money she sent to pay his mortgage.
- It is unknown if he is on good terms with his other brothers Jerry and Wyatt.
- He looked liked Ian in his first appearance though by his next, he looked different.
- He is the only one of Frank's brothers to make more than one appearance.
- Frank indirectly mentioned Clayton in "Gallavich!" when he remarks on how Ian's genes are odd even without Mickey. This is a callback to Ian really being the son of Clayton.