“Livin’ life to the fullest. I wouldn’t trade a day.”
Having just been diagnosed with stage 3 pancreatic cancer, she decides that she wants to live her remaining days "to the fullest" and leaves the clinic with Frank, who shows her the seedier side of life.
Bianca's family tries multiple times to convince her to undergo therapy, but she feels that it's useless since her cancer is late stage and the chances of her surviving are very low. During one of Frank and Bianca's drug and alcohol binges, Frank sends Bianca's sister a text with the address of the Gallagher household. Bianca feels betrayed and tries to escape her family and Frank, only to have Frank go with her to Costa Rica for the next few days where she wants to live out her last days.
During 5x12 Frank buys a gun, and Bianca accidentally shoots Frank in the arm during a game of Russian Roulette. Bianca is experiencing progressing cancer. The next morning, Bianca walks into the ocean, never to be seen again. She leaves Frank a goodbye note while thanking him for his care and likely committed suicide.
In Los Diablos, Frank mentions to Mikey o'shea on why he should be the ideal person for hobo loco by mentioning Bianca stating he buried "a cancer ridden girlfriend".
- She is one of the few characters to like Frank, despite his personality.